After yeast cells commit to the cell cycle in a process called START, genes required for DNA synthesis are expressed in late G1. Periodicity is mediated by a hexameric sequence, known as a MCB element, present in all DNA synthesis gene promoters. A complex that specifically binds MCBs has been identified. One polypeptide in the MCB complex is Swi6, a transcription factor that together with Swi4 also binds G1 cyclin promoters and participates in a positive feedback loop at START. The (...) finding that Swi6 is directly involved in both START and DNA synthesis gene control suggest a model in which Swi6, activated through its participation in START, serves as the central transcription factor in coordinating late G1 gene expression. The mechanism may be conserved in all eukaryotic cells. (shrink)

1 Cognitive Architectures 2 Multilayer Perceptrons 3 Relations between Variables 4 Structured Representations 5 Individuals 6 Where does the Machinery of Symbol Manipulation Come From? 7 Conclusions.

Collingwood statement in his autobiography that he became convinced of the need for the rapprochement between philosophy and history as early as 1919 must be taken seriously. The aim of this dissertation is to demonstrate the nature, soundness and continuity of Collingwood's conception of that rapprochement and to show how that rapprochement develops, and is based upon, the idea of progress. The themes of the rapprochement and the idea of progress are traced through all of Collingwood's major works in chronological (...) order. ;Part I elaborates how Speculum Mentis and An Essay on Philosophical Method complement each other as the springboard for Collingwood's later writings. In Speculum Mentis, Collingwood appeals to the dialectic of experience to explain the unique yet imprecisely defined interdependence of history and philosophy. An Essay on Philosophical Method is mainly an attempt to state the logic behind the earlier work. ;Part II covers The Idea of Nature, The Idea of History and The Principles of Art. In The Idea of Nature, Collingwood attempts to follow the method outlined in An Essay on Philosophical Method. The method used is significant, but even more telling is his conclusion that science turns into history. In The Idea of History, Collingwood attempts to define history and begins to fill in the details of the desired rapprochement and the notion of progress. In The Principles of Art, he explains his philosophy of mind, effectively moving from 'experience' to 'consciousness'. ;Part III focuses on the relationship between philosophy and history as articulated in An Autobiography and An Essay on Metaphysics. An Autobiography contains the most complete rendering of the logic of question-and-answer, a philosophical method which links philosophy to progress. In the work on metaphysics, Collingwood develops the culminating idea that the subject matter of metaphysics, absolute presuppositions, is historically grounded. The result is that a philosopher cannot simply study a theory, but must study its development as well. ;In Collingwood's view, philosophy is the only inquiry in which, from start to finish, history is self-consciously both studied and made. In coming to terms with history, philosophy must also come to terms with the notion of progress. Collingwood's presentation of the notion of progress goes far toward dispelling the notion that philosophy and history can only provide knowledge for its own sake. His dialectical philosophy shows how the recognition of the historical character of philosophy makes possible the original vocation of philosophy, the love of wisdom. (shrink)

Prior research suggests that voluntary environmental governance mechanisms operate to enhance a firm’s environmental legitimacy as opposed to being a driver of proactive environmental performance activities. To understand how these mechanisms contribute to the firm’s environmental legitimacy, we investigate whether environmental corporate governance characteristics are associated with voluntary environmental disclosure. We examine an increasingly important attribute of a firm’s disclosure setting, namely the disclosure of greenhouse gas (GHG) information. GHG information represents proprietary non-financial information about the firm’s exposure to environmental (...) concerns and is related to the firm’s operations and future profitability. Thus, we expect governance participants would view such information as a potentially important strategic device for managing stakeholders’ demands for information concerning environmental risks. We find that the presence of an environmental committee and a Chief Sustainability Officer (CSO) is positively associated with the likelihood of GHG disclosure and that CSOs are associated with disclosure transparency. Further analysis reveals that the likelihood of disclosure is associated with committee size, number of committee meetings, expertise of committee members and CSO, and overlap between the environmental committee and audit committee. Only expertise of the environmental committee members and the CSO are associated with GHG disclosure transparency, while larger committees tend to be associated with lower transparency. Our results are particularly important to those with interests in evaluating the potential role that corporate governance mechanisms play in responding to stakeholder concerns about environmental risks. Directors and officers who are considering appointment to similar governance positions, may wish to consider what attributes would make such governance positions more influential. (shrink)

The creation of a specialized executive position that oversees sustainability activities represents a distinct shift in the structure of top management teams and their approach for addressing sustainability concerns. However, little is known about these management team members, namely the corporate sustainability officers or CSOs. We examine CSO appointments and their association with subsequent sustainability performance. Our results indicate that the creation of a CSO position may represent more of a symbolic versus substantive governance mechanism. Further tests suggest that CSO (...) expertise and the firm’s existing sustainability performance affect the association between the CSO and post-appointment sustainability performance. We find no association between CSO appointments and subsequent sustainability performance for firms that were already poor performers, while firms possessing relatively higher levels of prior sustainability performance appointing a CSO begin to experience significant improvements to performance after 3 years. We further find that CSOs with prior sustainability expertise are associated with increases in sustainability performance in firms that were already strong performers, but not in firms with poor sustainability performance. Non-expert CSOs, on the other hand, are associated with initial decreases in performance for poor performing firms, whereas better performing firms hiring non-expert CSOs are able to rely on other sustainability attributes of the firm and benefit from improvements in performance in the long term. We discuss the potential importance of these positions as it relates to symbolic versus substantive governance mechanisms through the lens of top management team literature streams. (shrink)

The apparent very close similarity between the learning of the past tense by Adam and the Plunkett and Marchman model is exaggerated by several misleading comparisons--including arbitrary, unexplained changes in how graphs were plotted. The model's development differs from Adam's in three important ways: Children show a U-shaped sequence of development which does not depend on abrupt changes in input; U-shaped development in the simulation occurs only after an abrupt change in training regimen. Children overregularize vowel-change verbs more than no-change (...) verbs; the simulation overregularizes vowel-change verbs less often than no-change verbs. Children, including Adam, overregularize more than they irregularize; the simulation overregularized less than it irregularized. Interestingly, the RM model--widely criticized as being inadequate--does somewhat better, correctly overregularizing vowel-change verbs more often than no-change verbs, and overregularizing more often than it irregularizes. Although Plunkett and Marchman's (1993) state of the art model incorporated hidden layers and back-propagation, used a more realistic phonological coding scheme, and explored a broader range of parameters than Rumelhart and McClelland's model, their results are farther from psychological reality. It is unknown whether any connectionist model can mimic a child's performance without resorting to unrealistic exogenous changes in the training or input, but it is clear that adding a hidden-layer and back-propagation does not ensure a solution. (shrink)

Is the human tendency toward musicality better thought of as the product of a specific, evolved instinct or an acquired skill? Developmental and evolutionary arguments are considered, along with issues of domain‐specificity. The article also considers the question of why humans might be consistently and intensely drawn to music if musicality is not in fact the product of a specifically evolved instinct.

In The Tragedy of the Self, Gary F. Greif attributes social violence and individual isolation to a contemporary neglect of a fundamental human need for support that only human culture and interaction can promote and reinforce. Greif bases this interpretation on the works of Heinz Kohut, a psychoanalyst who by degrees transformed Freud's theory of the instincts into a theory of the self. Kohut maintains that every individual fundamentally requires continual human support in order to live with confidence and (...) hope. Greif introduces Kohut's understanding of the nature, development, and disintegration of the self, analyzes modern and contemporary assumptions regarding the individualistic, anti-social nature of humans, and concludes that contemporary societal assumptions regarding the acceptance of individualism reflect and perpetuate a tragic human condition. Greif argues that the inability of the self to experience a human, fulfilling life is a tragedy intensified by a century of economic and cultural forces promoting social antagonism. A unique and stimulating book, The Tragedy of the Self will appeal to professionals in psychoanalytic psychology, self-psychology, and philosophy as well as academics and students in the Humanities and Social Sciences. (shrink)

Rogers & McClelland's (R&M's) précis represents an important effort to address key issues in concepts and categorization, but few of the simulations deliver what is promised. We argue that the models are seriously underconstrained, importantly incomplete, and psychologically implausible; more broadly, R&M dwell too heavily on the apparent successes without comparable concern for limitations already noted in the literature.

This chapter examines an apparent tension created by recent research on neurological development and genetics on the one hand and cognitive development on the other. It considers what it might mean for intrinsic signals to guide the initial establishment of functional architecture. It argues that an understanding of the mechanisms by which the body develops can inform our understanding of the mechanisms by which the brain develops. It cites the view of developmental neurobiologists Fukuchi-Shimogori and Grove, that the patterning of (...) the part of the brain responsible for our higher functions is coordinated by the same basic mechanisms and signaling protein families used to generate patterning in other embryonic organs. Thus, what's good enough for the body, is good enough for the brain. (shrink)

Connectionist networks excel at extracting statistical regularities but have trouble extracting higher-order relationships. Clark & Thornton suggest that a solution to this problem might come from Elman, but I argue that the success of Elman's single recurrent network is illusory, and show that it cannot in fact represent abstract relationships that can be generalized to novel instances, undermining Clark & Thornton 's key arguments.

The mere fact that a particular aspect of mind could offer an adaptive advantage is not enough to show that that property was in fact shaped by that adaptive advantage. Although it is possible that the tendency towards positive illusion is an evolved misbelief, it it also possible that positive illusions could be a by-product of a broader, flawed cognitive mechanism that itself was shaped by accidents of evolutionary inertia.

This commentary discusses the logic of inferring modularity or the lack of modularity from observed patterns of developmental disorders.

We find the theory of neural reuse to be highly plausible, and suggest that human individual differences provide an additional line of argument in its favor, focusing on the well-replicated finding of in which individual differences are highly correlated across domains. We also suggest that the theory of neural reuse may be an important contributor to the phenomenon of positive manifold itself.

For centuries (indeed for millennia) philosophers have complained about pseudo-philosophy being practiced by others claiming to be philosophers — and about people being taken in and suffering in one way or another from the mimicry, exploitation, and fakery of the pseudo-philosophers. But no attempt at a careful, comprehensive, and useful characterization of pseudo-philosophy has emerged. This book is a comprehensive historical, theoretical, and practical treatment of pseudo-philosophy — a concept often encountered in both formal and popular philosophy, but rarely with (...) any degree of seriousness and precision. It presents a theory of pseudo-philosophy through the use of models of the genuine philosopher and pseudo-philosopher, and then applies that theory to specific real-world cases. -/- Available on Amazon in either KIndle or paperback format. More details — as well as the complete Preface, Postscript, and References sections — available on my False Wisdom blog (falsephilosophy on blogspot: see External Links below). (shrink)

The antisaccade task provides a model paradigm that sets the inhibition of a reflexively driven behaviour against the volitional control of a goal-directed behaviour. The stability and adaptability of antisaccade performance was investigated in 23 neurologically healthy individuals. Behaviour and brain function were measured using functional magnetic resonance imaging (fMRI) prior to and immediately following two weeks of daily antisaccade training. Participants performed antisaccade trials faster with no change in directional error rate following two weeks of training; however this increased (...) speed came at the cost of the spatial accuracy of the saccade (gain) which became more hypometric following training. Training on the antisaccade task resulted in increases in fMRI activity in the fronto-basal ganglia-parietal-cerebellar ocular motor network. Following training, antisaccade latency was positively associated with fMRI activity in the frontal and supplementary eye fields, anterior cingulate and intraparietal sulcus; antisaccade gain was negatively associated with fMRI activity in supplementary eye fields, anterior cingulate, intraparietal sulcus and cerebellar vermis. In sum, the results suggest that following training, larger antisaccade latency is associated with larger activity in fronto-parietal-cerebellar ocular motor regions, and smaller antisaccade gain is associated with larger activity in fronto-parietal ocular motor regions. (shrink)

In a series of papers over a period of several years Barry Smith andWerner Ceusters have offered a number of cogent criticisms of historical approaches to creating, maintaining, and applying biomedical terminologies and ontologies. And they have urged the adoption of what they refer to as a “realism-based” approach. Indeed, at times they insist that the realism-based approach not only offers clear advantages and a well-founded methodological basis for ontology development and evaluation, but that such a realist perspective is in (...) fact necessary for understanding and using terminologies and ontologies in science. -/- This paper explores a number of questions surrounding such claims, provides a careful characterization of the type of realism recommended by Smith and Ceusters, and evaluates the role that realism plays in the critiques and recommendations that they offer. The conclusion reached is that while Smith’s and Ceusters’ criticisms of prior practice in the treatment of ontologies and terminologies in medical informatics are often both perceptive and well founded, and while at least some of their own proposals demonstrate obvious merit and promise, none of this either follows from or requires the brand of realism that they propose. (shrink)

Philosophers frequently struggle with the relation of metaphysics to the everyday world, with its practical value, and with its relation to empirical science. This paper distinguishes several different models of the relation between philosophical ontology and applied (scientific) ontology that have been advanced in the history of philosopy. Adoption of a strong participation model for the philosophical ontologist in science is urged, and requirements and consequences of the participation model are explored. This approach provides both a principled view and justification (...) of the role of the philosophical ontologist in contemporary empirical science as well as guidelines for integrating philosophers and philosophical contributions into the practice of science. (shrink)

In “Ontological realism: Methodology or misdirection?” I offered a detailed critique of the position referred to as “realism” taken by Barry Smith and Werner Ceusters. This position is claimed to serve as the basis for a “realist methodology” that they seek to impose on the development of scientific ontologies, particularly within the biomedical sciences. Here, in part responding to a reply to those criticisms by Smith and Ceusters, I return the focus to an examination of fundamental incoherencies in this realist (...) approach and propose an alternative that is amenable to much of what Smith and Ceusters hope to accomplish. And I sketch what I believe is needed to advance ontology theory and practice in the sciences. (shrink)